CALL FOR PAPERS Cardiovascular and Cerebrovascular Aging–New Mechanisms and Insights The TRPA1 channel is a cardiac target of mIGF-1/SIRT1 signaling

نویسندگان

  • Valerio Pazienza
  • Cristoforo Pomara
  • Francesco Cappello
  • Raffaele Calogero
  • Matteo Carrara
  • Gianluigi Mazzoccoli
  • Manlio Vinciguerra
  • Giovanni Rotondo
چکیده

Valerio Pazienza,* Cristoforo Pomara,* Francesco Cappello, Raffaele Calogero, Matteo Carrara, Gianluigi Mazzoccoli,* and Manlio Vinciguerra* Division of Gastroenterology, Department of Medical Sciences, IRCCS Scientific Institute “Casa Sollievo della Sofferenza,” San Giovanni Rotondo, Italy; Department of Anatomy, University of Malta, Msida, Malta; Department of Forensic Pathology, University of Foggia, Foggia, Italy; Department of Experimental Medicine and Clinical Neuroscience, Section of Human Anatomy, University of Palermo, Palermo, Italy; Euro-Mediterranean Institute of Science and Technology, Palermo, Italy; Molecular Biotechnology Center, University of Turin, Turin, Italy; Division of Internal Medicine and Chronobiology Unit, Department of Medical Sciences, IRCCS Scientific Institute “Casa Sollievo della Sofferenza,” San Giovanni Rotondo, Italy; and Division of Medicine, University College London, London, United Kingdom.

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The TRPA1 channel is a cardiac target of mIGF-1/SIRT1 signaling.

Cardiac overexpression of locally acting muscle-restricted (m)IGF-1 and the consequent downstream activation of NAD(+)-dependent protein deacetylase sirtuin 1 (SIRT1) trigger potent cardiac antioxidative and antihypertrophic effects. Transient receptor potential (TRP) cation channel A1 (TRPA1) belongs to the TRP ion channel family of molecular detectors of thermal and chemical stimuli that acti...

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تاریخ انتشار 2014